|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:beta-catenin
|
|
gptkbp:binds
|
gptkb:TCF/LEF_transcription_factors
|
|
gptkbp:degradedBy
|
gptkb:APC_protein
Axin complex
GSK-3beta
|
|
gptkbp:discoveredBy
|
Rolf Kemler
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
gptkb:CTNNB1_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
cell adhesion
|
|
gptkbp:interactsWith
|
gptkb:APC_protein
gptkb:Axin
gptkb:cadherins
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3p22.1
|
|
gptkbp:molecularWeight
|
~85 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:medulloblastoma
colorectal cancer
hepatocellular carcinoma
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gene transcription
|
|
gptkbp:role
|
gptkb:cancer
gptkb:immune_response
gptkb:synaptic_plasticity
cell differentiation
cell proliferation
embryonic development
angiogenesis
cell migration
inflammation
bone formation
organogenesis
neural development
learning and memory
tissue homeostasis
liver regeneration
cardiac development
epithelial-mesenchymal transition
stem cell renewal
hair follicle development
|
|
gptkbp:structure
|
contains armadillo repeats
|
|
gptkbp:UniProtID
|
gptkb:P35222
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1_gene
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Catenin beta-1 protein
|