Catenin beta-1 protein

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:beta-catenin
gptkbp:binds gptkb:TCF/LEF_transcription_factors
gptkbp:degradedBy gptkb:APC_protein
Axin complex
GSK-3beta
gptkbp:discoveredBy Rolf Kemler
gptkbp:discoveredIn 1992
gptkbp:encodedBy gptkb:CTNNB1_gene
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function gptkb:Wnt_signaling_pathway
cell adhesion
https://www.w3.org/2000/01/rdf-schema#label Catenin beta-1 protein
gptkbp:interactsWith gptkb:APC_protein
gptkb:Axin
gptkb:cadherins
gptkbp:locale gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:chromosome_3p22.1
gptkbp:molecularWeight ~85 kDa
gptkbp:mutationAssociatedWith gptkb:medulloblastoma
colorectal cancer
hepatocellular carcinoma
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates gene transcription
gptkbp:role gptkb:cancer
gptkb:synaptic_plasticity
cell differentiation
cell proliferation
embryonic development
angiogenesis
cell migration
inflammation
immune response
bone formation
organogenesis
neural development
learning and memory
tissue homeostasis
liver regeneration
cardiac development
epithelial-mesenchymal transition
stem cell renewal
hair follicle development
gptkbp:structure contains armadillo repeats
gptkbp:UniProtID gptkb:P35222
gptkbp:bfsParent gptkb:CTNNB1_gene
gptkbp:bfsLayer 7