aryl hydrocarbon receptor (AhR)
GPTKB entity
Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:activatedBy |
dioxins
polycyclic aromatic hydrocarbons tryptophan metabolites |
| gptkbp:alias |
AhR
bHLHe76 aryl hydrocarbon receptor nuclear translocator-interacting protein |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases inflammatory diseases |
| gptkbp:discoveredBy |
1976
|
| gptkbp:encodedBy |
AHR gene
|
| gptkbp:formsComplexWith |
ARNT (aryl hydrocarbon receptor nuclear translocator)
|
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
modulation of immune response
regulation of biological response to planar aromatic hydrocarbons xenobiotic metabolism regulation |
| gptkbp:gene |
gptkb:AHR
|
| gptkbp:HGNC_ID |
348
|
| https://www.w3.org/2000/01/rdf-schema#label |
aryl hydrocarbon receptor (AhR)
|
| gptkbp:interactsWith |
gptkb:HSP90
p23 AIP (aryl hydrocarbon receptor-interacting protein) |
| gptkbp:involves |
cell differentiation
cell proliferation immune system regulation developmental processes toxic response to environmental pollutants |
| gptkbp:locatedOnChromosome |
7p21
|
| gptkbp:location |
cytoplasm (inactive)
nucleus (active) |
| gptkbp:member |
gptkb:basic_helix-loop-helix_(bHLH)_family
PAS domain-containing proteins |
| gptkbp:modulatedBy |
phytochemicals
microbial metabolites endogenous ligands exogenous ligands |
| gptkbp:regulates |
inflammatory cytokine production
intestinal homeostasis immune cell differentiation skin barrier function CYP1A1 gene expression CYP1B1 gene expression Treg/Th17 cell balance phase I and II detoxification enzymes |
| gptkbp:UniProtID |
P35869
|
| gptkbp:bfsParent |
gptkb:CYP1A2
gptkb:CYP1_family |
| gptkbp:bfsLayer |
5
|