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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alsoKnownAs
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gptkb:SDF1
|
|
gptkbp:associatedWith
|
HIV infection
inflammatory diseases
cancer metastasis
|
|
gptkbp:component
|
extracellular region
|
|
gptkbp:discoveredBy
|
gptkb:Tashiro_et_al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
gptkb:C-X-C_motif_chemokine_ligand_12
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000107562
6387
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
heart
liver
bone marrow
|
|
gptkbp:function
|
cell signaling
chemokine activity
regulation of hematopoiesis
regulation of immune cell migration
|
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gptkbp:GOProcess
|
immune response
chemotaxis
|
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gptkbp:hasParalog
|
gptkb:CXCL11
gptkb:CXCL13
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CXCL12 gene
|
|
gptkbp:length
|
89 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q11.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:WHIM_syndrome
|
|
gptkbp:OMIM
|
600835
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cxcl12
|
|
gptkbp:product
|
monomeric
contains CXC motif
|
|
gptkbp:proteinFamily
|
CXC chemokine family
|
|
gptkbp:recipient
|
gptkb:CXCR4
gptkb:ACKR3
|
|
gptkbp:regulates
|
angiogenesis
neuronal development
tumor growth
stem cell homing
leukocyte trafficking
|
|
gptkbp:significance
|
target for cancer therapy
target for HIV therapy
target for stem cell mobilization
|
|
gptkbp:UniProtID
|
gptkb:P48061
|
|
gptkbp:bfsParent
|
gptkb:SDF-1
|
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gptkbp:bfsLayer
|
7
|