CHEMBL458

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:approvalYear 2001
gptkbp:approvedBy gptkb:gastrointestinal_stromal_tumor
gptkb:chronic_myeloid_leukemia
gptkbp:ATCCode L01EA01
gptkbp:bioavailability 98%
gptkbp:CASNumber 152459-95-5
gptkbp:developedBy gptkb:Novartis
gptkbp:drugClass protease inhibitor
gptkbp:eliminatedIn renal
hepatic
biliary
gptkbp:eliminationHalfLife 18 hours
gptkbp:excretion urine
bile
feces
gptkbp:FDAApproved yes
gptkbp:hasCYPInteraction CYP2D6 inhibitor
CYP2C9 inhibitor
CYP3A4 substrate
gptkbp:hasInChIKey gptkb:KHGXJUYNMMXHFG-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C29H31N7O
gptkbp:hasPatent gptkb:US5521184A
gptkbp:hasSMILES CC1=CC=CC=C1NC(=O)C2=CC=CC=C2C3=NC=CC(=N3)N4CCN(CC4)C5=NC=CC=N5
gptkbp:hasUNII 8LJ08TK9A1
https://www.w3.org/2000/01/rdf-schema#label CHEMBL458
gptkbp:indication gptkb:Philadelphia_chromosome-positive_chronic_myeloid_leukemia
gptkb:Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction gptkb:receptor_tyrosine_kinase
gptkbp:metabolism liver (CYP3A4)
gptkbp:molecularWeight 493.6
gptkbp:name gptkb:Imatinib
gptkbp:pregnancyCategory D (US)
gptkbp:proteinBinding 95%
gptkbp:PubChem_CID gptkb:CHEBI:45783
gptkb:CHEMBL458
gptkb:DB00619
5291
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
edema
rash
muscle cramps
gptkbp:synonym gptkb:Gleevec
gptkb:STI-571
gptkbp:target gptkb:BCR-ABL
gptkb:PDGFR
gptkb:c-Kit
gptkbp:therapeuticArea oncology
gptkbp:bfsParent gptkb:zidovudine
gptkbp:bfsLayer 6