Philadelphia chromosome-positive chronic myeloid leukemia

URI: https://gptkb.org/entity/Philadelphia_chromosome-positive_chronic_myeloid_leukemia

GPTKB entity

Statements (52)

Predicate	Object
gptkbp:instanceOf	gptkb:disease leukemia
gptkbp:abbreviation	Ph+ CML
gptkbp:causedBy	BCR-ABL1 fusion gene
gptkbp:complication	gptkb:anemia thrombocytopenia blast crisis leukostasis
gptkbp:firstDescribed	1960
gptkbp:hasBiomarker	BCR-ABL1
gptkbp:hasBloodFinding	eosinophilia leukocytosis basophilia
gptkbp:hasChromosomalAbnormality	gptkb:Philadelphia_chromosome
gptkbp:hasDiagnosticMethod	cytogenetic analysis FISH for BCR-ABL1 RT-PCR for BCR-ABL1
gptkbp:hasEpidemiology	slightly more common in males more common in adults
gptkbp:hasGeneticTranslocation	t(9;22)(q34;q11)
gptkbp:hasNamedAfter	gptkb:Philadelphia,_Pennsylvania
gptkbp:hasOrphanetID	ORPHA:99860
gptkbp:hasParentDisease	gptkb:chronic_myeloid_leukemia
gptkbp:hasSurvivalRate	5-year survival >80% with treatment
https://www.w3.org/2000/01/rdf-schema#label	Philadelphia chromosome-positive chronic myeloid leukemia
gptkbp:ICD-10_code	C92.1
gptkbp:incidence	1-2 per 100,000 per year
gptkbp:medianAge	50-60 years
gptkbp:OMIM	608232
gptkbp:originatedIn	myeloid lineage hematopoietic stem cell
gptkbp:pathology	constitutive tyrosine kinase activity
gptkbp:period	accelerated phase blast crisis chronic phase
gptkbp:prevalence	rare in children
gptkbp:prognosis	generally favorable with treatment
gptkbp:riskFactor	exposure to ionizing radiation
gptkbp:symptom	gptkb:anemia fatigue splenomegaly weight loss night sweats
gptkbp:treatment	gptkb:bosutinib gptkb:dasatinib gptkb:ponatinib gptkb:imatinib gptkb:nilotinib hematopoietic stem cell transplantation tyrosine kinase inhibitors
gptkbp:bfsParent	gptkb:Scemblix
gptkbp:bfsLayer	6