gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:drug
|
gptkbp:administeredBy
|
gptkb:tablet
|
gptkbp:approvalYear
|
2001
|
gptkbp:approvedBy
|
gptkb:FDA
|
gptkbp:ATCCode
|
L01EA01
|
gptkbp:brand
|
gptkb:Gleevec
gptkb:Glivec
|
gptkbp:CASNumber
|
152459-95-5
|
gptkbp:category
|
protease inhibitor
antineoplastic agent
orphan drug
|
gptkbp:contraindication
|
pregnancy
hypersensitivity to imatinib
|
gptkbp:cost
|
high (in US, before generics)
|
gptkbp:developedBy
|
gptkb:Novartis
|
gptkbp:discoveredBy
|
gptkb:Brian_Druker
gptkb:Nicholas_Lydon
|
gptkbp:eliminationHalfLife
|
18 hours
|
gptkbp:excretion
|
urine
feces
|
gptkbp:firstSynthesized
|
1992
|
gptkbp:genericAvailable
|
yes
|
gptkbp:hasMolecularFormula
|
C29H31N7O
|
https://www.w3.org/2000/01/rdf-schema#label
|
Imatinib
|
gptkbp:interactsWith
|
CYP3A4 inhibitors
CYP3A4 inducers
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
inhibits BCR-ABL tyrosine kinase
inhibits c-KIT
inhibits PDGF receptor
|
gptkbp:metabolism
|
liver (CYP3A4)
|
gptkbp:molecularWeight
|
493.6 g/mol
|
gptkbp:patentExpired
|
yes
|
gptkbp:pregnancyCategory
|
D (US)
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL941
5291
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
nausea
diarrhea
edema
fatigue
rash
muscle cramps
|
gptkbp:UNII
|
8CIP0O835V
|
gptkbp:usedFor
|
gptkb:gastrointestinal_stromal_tumor
gptkb:chronic_myeloid_leukemia
gptkb:systemic_mastocytosis
gptkb:dermatofibrosarcoma_protuberans
leukemia
hypereosinophilic syndrome
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
gptkbp:bfsParent
|
gptkb:CHEMBL958
gptkb:112809-51-5
|
gptkbp:bfsLayer
|
6
|