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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
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gptkb:cyclin-dependent_kinase_inhibitor_1
gptkb:p21
gptkb:CIP1
gptkb:WAF1
|
|
gptkbp:category
|
tumor suppressor
cell cycle protein
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
Xiong et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:CDKN1A_gene
|
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gptkbp:Entrez_Gene_ID
|
1026
|
|
gptkbp:function
|
cell cycle inhibitor
inhibits cyclin-CDK2 or -CDK1 complexes
regulation of cell cycle G1 phase
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|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN1A (p21) protein
|
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gptkbp:inducedBy
|
DNA damage
p53 activation
|
|
gptkbp:inhibitedBy
|
cell proliferation
DNA replication
|
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gptkbp:interactsWith
|
gptkb:cyclin_A
gptkb:GADD45
gptkb:CDK2
gptkb:PCNA
gptkb:cyclin_E
gptkb:CDK1
|
|
gptkbp:length
|
164 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:OMIM
|
116899
|
|
gptkbp:orthologIn
|
mouse Cdkn1a
rat Cdkn1a
|
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gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
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gptkbp:regulates
|
regulated by p53
|
|
gptkbp:role
|
apoptosis
cellular senescence
DNA damage response
tumor suppression
|
|
gptkbp:significance
|
mutations associated with cancer
biomarker for cell cycle arrest
|
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gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains CDK inhibitor domain
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
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gptkbp:bfsParent
|
gptkb:CIZ1
|
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gptkbp:bfsLayer
|
7
|