|
gptkbp:instanceOf
|
gptkb:protein
cell surface receptor
|
|
gptkbp:alternativeName
|
gptkb:Fas
gptkb:APO-1
gptkb:TNFRSF6
|
|
gptkbp:associatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
gptkb:cancer
gptkb:liver_disease
|
|
gptkbp:discoveredBy
|
gptkb:Peter_H._Krammer
|
|
gptkbp:encodedBy
|
gptkb:FAS_gene
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
various tissues
lymphocytes
|
|
gptkbp:function
|
induces apoptosis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD95 (Fas receptor)
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-8
gptkb:caspase-10
|
|
gptkbp:ligand
|
gptkb:Fas_ligand_(FasL)
|
|
gptkbp:locatedOnChromosome
|
10q23
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:mutationAssociatedWith
|
immune dysregulation
impaired apoptosis
|
|
gptkbp:OMIM
|
134637
|
|
gptkbp:orthologInMouse
|
gptkb:Fas_(mouse)
|
|
gptkbp:pathway
|
extrinsic apoptotic signaling pathway
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
therapeutic antibodies
experimental cancer therapies
|
|
gptkbp:UniProtID
|
gptkb:P25445
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:bfsLayer
|
7
|