|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:membrane_cofactor_protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:atypical_hemolytic_uremic_syndrome
gptkb:systemic_lupus_erythematosus
multiple sclerosis
pre-eclampsia
|
|
gptkbp:biologicalProcess
|
cofactor for factor I-mediated cleavage of C3b and C4b
|
|
gptkbp:discoveredBy
|
Liszewski et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
CD46 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000117335
4179
|
|
gptkbp:expressedIn
|
most nucleated cells
|
|
gptkbp:function
|
regulation of complement activation
protection of host cells from complement-mediated damage
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:CD46
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD46 gene
|
|
gptkbp:interactsWith
|
gptkb:virus
gptkb:Neisseria_gonorrhoeae
gptkb:measles_virus
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q32
|
|
gptkbp:numberOfExons
|
14
|
|
gptkbp:OMIM
|
120900
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:product
|
gptkb:CD46
type I membrane protein
|
|
gptkbp:UniProtID
|
gptkb:P15529
|
|
gptkbp:bfsParent
|
gptkb:CD46
|
|
gptkbp:bfsLayer
|
8
|