Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:CD46
|
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:cellularComponent |
gptkb:cell_membrane
|
| gptkbp:discoveredBy |
multiple research groups in the 1980s
|
| gptkbp:encodedBy |
gptkb:CD46_gene
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000117335
4179 |
| gptkbp:expressedIn |
many human tissues
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
cofactor for factor I-mediated cleavage of C3b and C4b
regulation of complement activation |
| gptkbp:glycosylation |
N-linked glycosylation
|
| https://www.w3.org/2000/01/rdf-schema#label |
membrane cofactor protein
|
| gptkbp:interactsWith |
complement component C4b
factor I complement component C3b |
| gptkbp:length |
350-400 amino acids (isoform dependent)
|
| gptkbp:locatedOnChromosome |
1q32
|
| gptkbp:OMIM |
120900
|
| gptkbp:role |
immune response
|
| gptkbp:significance |
deficiency associated with atypical hemolytic uremic syndrome
|
| gptkbp:structure |
type I membrane protein
|
| gptkbp:UniProtID |
gptkb:P15529
|
| gptkbp:usedAs |
receptor for Neisseria gonorrhoeae
receptor for certain viruses receptor for human herpesvirus 6 receptor for measles virus |
| gptkbp:bfsParent |
gptkb:CD46
|
| gptkbp:bfsLayer |
8
|