|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:ATK
gptkb:BPK
gptkb:BTK
XLA
AGMX1
IMD1
PSCTK1
|
|
gptkbp:associatedWith
|
gptkb:X-linked_agammaglobulinemia
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Ogden_Bruton
|
|
gptkbp:domain
|
gptkb:PH_domain
kinase domain
SH2 domain
SH3 domain
|
|
gptkbp:enzymeClassification
|
EC 2.7.10.2
|
|
gptkbp:expressedIn
|
gptkb:B_cells
myeloid cells
|
|
gptkbp:function
|
signal transduction
B cell development
|
|
gptkbp:gene
|
gptkb:BTK_gene
gptkb:BTK
|
|
gptkbp:HGNC_ID
|
HGNC:1133
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bruton tyrosine kinase
|
|
gptkbp:involves
|
gptkb:PI3K-Akt_signaling_pathway
gptkb:B_cell_receptor_signaling_pathway
gptkb:NF-κB_signaling_pathway
|
|
gptkbp:length
|
659 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:X_chromosome
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
76 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:X-linked_agammaglobulinemia
immunodeficiency
|
|
gptkbp:OMIM
|
300300
|
|
gptkbp:orthologInMouse
|
gptkb:Btk
|
|
gptkbp:PDB
|
3GEN
5P9J
6E4F
|
|
gptkbp:phosphorylates
|
Y223
Y551
|
|
gptkbp:proteinFamily
|
gptkb:Tec_family_kinases
|
|
gptkbp:reviewedBy
|
gptkb:The_Journal_of_Immunology
gptkb:Nature_Reviews_Immunology
|
|
gptkbp:targetOfDrug
|
gptkb:acalabrutinib
gptkb:ibrutinib
zanubrutinib
|
|
gptkbp:UniProtID
|
Q06187
|
|
gptkbp:bfsParent
|
gptkb:acalabrutinib
|
|
gptkbp:bfsLayer
|
7
|