Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Bruton_tyrosine_kinase_inhibitor
gptkb:acalabrutinib |
| gptkbp:associated_with |
immune response
autoimmune diseases inflammatory diseases B-cell development |
| gptkbp:clinical_trial |
target for cancer therapy
|
| gptkbp:discovered_by |
gptkb:Dr._Thomas_Bruton
|
| gptkbp:established |
gptkb:GS-4059
gptkb:LOXO-305 gptkb:TGR-1202 gptkb:Zanubrutinib gptkb:ABBV-181 gptkb:Ibrutinib gptkb:Acalabrutinib BGB-3111 PRN-2246 |
| gptkbp:function |
phosphorylates proteins
|
| gptkbp:genetic_diversity |
affects antibody production
causes X-linked agammaglobulinemia impairs B-cell maturation |
| https://www.w3.org/2000/01/rdf-schema#label |
Bruton tyrosine kinase
|
| gptkbp:is_a_route_for |
MAPK signaling pathway
NF-k B signaling pathway B-cell receptor pathway |
| gptkbp:is_involved_in |
T-cell activation
apoptosis regulation biomarker discovery cell differentiation cell proliferation clinical trials drug development genetic studies molecular diagnostics personalized medicine therapeutic strategies cell survival pharmacogenomics tumor microenvironment immune tolerance cell adhesion cell migration combination therapies cytokine production therapeutic resistance cancer metastasis immune cell signaling B-cell activation B-cell receptor signaling lymphocyte activation antigen receptor signaling chronic inflammatory response |
| gptkbp:is_represented_in |
B-cells
|
| gptkbp:located_in |
cytoplasm
|
| gptkbp:promoter |
BTK
|
| gptkbp:related_to |
gptkb:healthcare_organization
mantle cell lymphoma |
| gptkbp:role |
signal transduction
|