|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:X-linked_agammaglobulinemia
immunodeficiency
|
|
gptkbp:discoveredBy
|
gptkb:Ogden_Bruton
|
|
gptkbp:Entrez_Gene_ID
|
695
|
|
gptkbp:enzymeClassification
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:fullName
|
Bruton's tyrosine kinase
|
|
gptkbp:function
|
signal transduction in B cells
|
|
gptkbp:gene
|
gptkb:BTK
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1129
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Btk
|
|
gptkbp:inhibitedBy
|
gptkb:acalabrutinib
gptkb:ibrutinib
spebrutinib
tirabrutinib
zanubrutinib
|
|
gptkbp:KEGGID
|
hsa:695
|
|
gptkbp:locatedOn
|
gptkb:X_chromosome
|
|
gptkbp:locatedOnChromosome
|
Xq21.3-q22
|
|
gptkbp:molecularWeight
|
76 kDa
|
|
gptkbp:mutationAssociatedWith
|
impaired B cell development
|
|
gptkbp:numberOfExons
|
19
|
|
gptkbp:OMIM
|
300300
|
|
gptkbp:orthologInMouse
|
gptkb:Btk
|
|
gptkbp:pathway
|
gptkb:B_cell_receptor_signaling_pathway
gptkb:Toll-like_receptor_signaling_pathway
Fc epsilon RI signaling pathway
|
|
gptkbp:PDB
|
3GEN
|
|
gptkbp:product
|
BTK protein
|
|
gptkbp:Reactome
|
R-HSA-1168372
|
|
gptkbp:UniProtID
|
Q06187
|
|
gptkbp:bfsParent
|
gptkb:Tec_family_kinases
|
|
gptkbp:bfsLayer
|
7
|