|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:BCL2L2
BCL2-like 2 protein
Bcl2-L-2
|
|
gptkbp:biologicalProcess
|
cell survival
tumorigenesis
spermatogenesis
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:Entrez_Gene_ID
|
599
ENSG00000140943
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:testis
brain
liver
colon
|
|
gptkbp:function
|
anti-apoptotic protein
|
|
gptkbp:gene
|
gptkb:BCL2L2
|
|
gptkbp:HGNC_ID
|
1002
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bcl-w
|
|
gptkbp:inhibitedBy
|
caspase activation
cytochrome c release
|
|
gptkbp:interactsWith
|
gptkb:Bcl-2
gptkb:Bcl-xL
gptkb:Bid
gptkb:PUMA
gptkb:Bax
gptkb:Bim
gptkb:Bak
Bad
|
|
gptkbp:locatedIn
|
mitochondrial outer membrane
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q11.2
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased apoptosis
male infertility in mice
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
1O0L
|
|
gptkbp:proteinFamily
|
gptkb:Bcl-2_family
|
|
gptkbp:RefSeq
|
NM_138761
|
|
gptkbp:regulates
|
apoptosis
regulated by microRNAs
transcriptionally regulated by p53
|
|
gptkbp:role
|
gptkb:cancer
neurodegenerative diseases
ischemic injury
|
|
gptkbp:structure
|
contains BH1, BH2, BH3, BH4 domains
|
|
gptkbp:UniProtID
|
Q92843
|
|
gptkbp:bfsParent
|
gptkb:Bcl-2_protein_family
gptkb:Bcl-2_family_proteins
|
|
gptkbp:bfsLayer
|
7
|