B-cell lymphoma 2 (Bcl-2) protein

URI: https://gptkb.org/entity/B-cell_lymphoma_2_(Bcl-2)_protein
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:Bcl2
gptkbp:associatedWith gptkb:cancer
follicular lymphoma
gptkbp:discoveredBy B-cell lymphoma
gptkbp:encodedBy gptkb:BCL2_gene
gptkbp:function regulation of apoptosis
anti-apoptotic protein
gptkbp:gene gptkb:BCL2
https://www.w3.org/2000/01/rdf-schema#label B-cell lymphoma 2 (Bcl-2) protein
gptkbp:inhibitedBy apoptosis
cytochrome c release
gptkbp:interactsWith Bak protein
Bad protein
Bax protein
gptkbp:involves cell survival
oncogenesis
mitochondrial integrity
lymphoma development
gptkbp:locatedIn outer mitochondrial membrane
gptkbp:locatedOnChromosome 18q21.33
gptkbp:member gptkb:Bcl-2_protein_family
gptkbp:molecularWeight 26 kDa
gptkbp:mutationAssociatedWith drug resistance
gptkbp:overexpression_leads_to tumorigenesis
gptkbp:PDB gptkb:1G5M
gptkbp:structure contains BH1, BH2, BH3, BH4 domains
gptkbp:target gptkb:oblimersen
gptkb:venetoclax
anticancer drugs
gptkbp:UniProtID P10415
gptkbp:bfsParent gptkb:Bcl-2_family_proteins
gptkbp:bfsLayer 7