|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:BCL2-like_1_protein
gptkb:BCL2L1
|
|
gptkbp:alternativeSplicing
|
gptkb:Bcl-xS
|
|
gptkbp:binds
|
pro-apoptotic proteins
|
|
gptkbp:encodedBy
|
gptkb:BCL2L1_gene
|
|
gptkbp:Entrez_Gene_ID
|
598
ENSG00000171552
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:function
|
anti-apoptotic protein
|
|
gptkbp:HGNC_ID
|
1001
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bcl-xL
|
|
gptkbp:inhibitedBy
|
gptkb:ABT-737
gptkb:Navitoclax
apoptosis
A-1331852
|
|
gptkbp:interactsWith
|
gptkb:Bid
gptkb:Bax
gptkb:Bim
gptkb:Bak
Bad
|
|
gptkbp:locale
|
mitochondrial outer membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:20q11.21
|
|
gptkbp:memberOf
|
gptkb:Bcl-2_protein_family
|
|
gptkbp:molecularWeight
|
~26 kDa
|
|
gptkbp:OMIM
|
600039
|
|
gptkbp:overexpressedIn
|
many cancers
|
|
gptkbp:PDB
|
gptkb:1R2D
|
|
gptkbp:phosphorylates
|
gptkb:Ser62
gptkb:Thr47
|
|
gptkbp:RefSeq
|
NM_138578
|
|
gptkbp:regulates
|
mitochondrial membrane permeability
|
|
gptkbp:role
|
cell survival
neuroprotection
hematopoiesis
chemoresistance
|
|
gptkbp:structure
|
contains BH domains
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:Q07817
|
|
gptkbp:bfsParent
|
gptkb:BAD_(Bcl-2-associated_death_promoter)
gptkb:BAD_protein
|
|
gptkbp:bfsLayer
|
6
|