Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
gptkb:BMP_receptors
|
| gptkbp:conservedIn |
cysteine knot motif
|
| gptkbp:discoveredBy |
John Wozney
|
| gptkbp:downstreamOf |
gene transcription regulation
|
| gptkbp:enemyOf |
gptkb:Chordin
gptkb:Follistatin gptkb:Noggin |
| gptkbp:example |
gptkb:BMP9
gptkb:BMP10 gptkb:BMP2 gptkb:BMP4 gptkb:BMP7 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:firstDescribed |
1988
|
| gptkbp:fullName |
Bone Morphogenetic Protein ligands
|
| gptkbp:function |
regulation of embryonic development
regulation of bone and cartilage development regulation of cell growth and differentiation |
| https://www.w3.org/2000/01/rdf-schema#label |
BMP ligands
|
| gptkbp:inhibitedBy |
extracellular antagonists
|
| gptkbp:involvedIn |
apoptosis
angiogenesis mesoderm induction patterning of embryonic tissues |
| gptkbp:memberOf |
gptkb:TGF-beta_superfamily
|
| gptkbp:mutationAssociatedWith |
developmental defects
skeletal disorders |
| gptkbp:orthologIn |
invertebrates
vertebrates |
| gptkbp:pathway |
gptkb:SMAD_pathway
|
| gptkbp:proteinFamily |
BMP gene family
|
| gptkbp:recipient |
serine/threonine kinase receptors
|
| gptkbp:role |
organogenesis
kidney development neural development immune regulation heart development lung development hair follicle development limb development osteogenesis tooth development |
| gptkbp:secretes |
cells
|
| gptkbp:structure |
dimeric proteins
|
| gptkbp:usedIn |
tissue engineering
regenerative medicine bone grafts |
| gptkbp:bfsParent |
gptkb:BMP_signaling_pathway
|
| gptkbp:bfsLayer |
7
|