|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
activin-binding protein
follistatin-related protein
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodedBy
|
gptkb:FST_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134352
10468
|
|
gptkbp:expressedIn
|
gptkb:skin
gptkb:pituitary_gland
gptkb:skeletal_muscle
gptkb:placenta
gptkb:testis
liver
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
regulates follicle-stimulating hormone secretion
regulates muscle growth
binds and neutralizes activin
inhibits myostatin
|
|
gptkbp:HGNC_ID
|
3976
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Follistatin
|
|
gptkbp:inhibitedBy
|
gptkb:bone_morphogenetic_proteins
myostatin
activin A
|
|
gptkbp:locatedOnChromosome
|
gptkb:5q11.2
|
|
gptkbp:molecularWeight
|
31-39 kDa (depending on isoform)
|
|
gptkbp:OMIM
|
136470
|
|
gptkbp:potentialTherapyFor
|
infertility
muscular dystrophy
fibrotic diseases
muscle wasting diseases
|
|
gptkbp:relatedTo
|
gptkb:cancer
fibrosis
muscle hypertrophy
tissue repair
reproductive system regulation
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:UniProtID
|
gptkb:P19883
|
|
gptkbp:usedIn
|
biomedical research
|
|
gptkbp:bfsParent
|
gptkb:BMP_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|