Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
oncoprotein |
| gptkbp:cause |
uncontrolled cell proliferation
|
| gptkbp:discoveredBy |
gptkb:Janet_Rowley
|
| gptkbp:foundIn |
gptkb:chronic_myeloid_leukemia
leukemia |
| gptkbp:function |
constitutive kinase activity
|
| gptkbp:hasBiologicalActivity |
tyrosine kinase activity
|
| gptkbp:hasBiomarker |
gptkb:Philadelphia_chromosome-positive_leukemia
|
| gptkbp:hasGeneFusion |
gptkb:ABL1_gene
BCR gene |
| gptkbp:hasIsoform |
p190
p210 p230 |
| https://www.w3.org/2000/01/rdf-schema#label |
BCR-ABL tyrosine kinase
|
| gptkbp:isTargetFor |
tyrosine kinase inhibitors
|
| gptkbp:locatedOnChromosome |
gptkb:Philadelphia_chromosome
|
| gptkbp:molecularWeight |
210 kDa
|
| gptkbp:mutationAssociatedWith |
E255K
T315I Y253F |
| gptkbp:pathway |
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway gptkb:RAS/MAPK_pathway |
| gptkbp:product |
gptkb:t(9;22)(q34;q11)_translocation
|
| gptkbp:target |
gptkb:bosutinib
gptkb:dasatinib gptkb:ponatinib gptkb:imatinib gptkb:nilotinib |
| gptkbp:bfsParent |
gptkb:chronic_myeloid_leukemia
|
| gptkbp:bfsLayer |
6
|