|
gptkbp:instanceOf
|
gptkb:protein
gptkb:oncoprotein
|
|
gptkbp:cause
|
uncontrolled cell proliferation
|
|
gptkbp:discoveredBy
|
gptkb:Janet_Rowley
|
|
gptkbp:foundIn
|
gptkb:leukemia
gptkb:chronic_myeloid_leukemia
|
|
gptkbp:function
|
constitutive kinase activity
|
|
gptkbp:hasBiologicalActivity
|
tyrosine kinase activity
|
|
gptkbp:hasBiomarker
|
gptkb:Philadelphia_chromosome-positive_leukemia
|
|
gptkbp:hasGeneFusion
|
gptkb:ABL1_gene
BCR gene
|
|
gptkbp:hasIsoform
|
p190
p210
p230
|
|
gptkbp:isTargetFor
|
tyrosine kinase inhibitors
|
|
gptkbp:locatedOnChromosome
|
gptkb:Philadelphia_chromosome
|
|
gptkbp:molecularWeight
|
210 kDa
|
|
gptkbp:mutationAssociatedWith
|
E255K
T315I
Y253F
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
gptkb:RAS/MAPK_pathway
|
|
gptkbp:product
|
gptkb:t(9;22)(q34;q11)_translocation
|
|
gptkbp:target
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
|
|
gptkbp:bfsParent
|
gptkb:chronic_myeloid_leukemia
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BCR-ABL tyrosine kinase
|