|
gptkbp:instance_of
|
gptkb:healthcare_organization
|
|
gptkbp:bfsLayer
|
4
|
|
gptkbp:bfsParent
|
gptkb:Gleevec
|
|
gptkbp:affects
|
blood cells
|
|
gptkbp:associated_with
|
gptkb:fandom
gptkb:BCR-ABL_fusion_gene
thrombocytopenia
poor prognosis
increased white blood cell count
|
|
gptkbp:can_lead_to
|
gptkb:chronic_myeloid_leukemia
gptkb:healthcare_organization
blast crisis
|
|
gptkbp:caused_by
|
hepatomegaly
splenomegaly
|
|
gptkbp:clinical_trial
|
ongoing research
|
|
gptkbp:duration
|
long-term therapy
|
|
gptkbp:first_described_by
|
1960s
|
|
gptkbp:genetic_diversity
|
BCR-AB L1
|
|
gptkbp:has_achievements
|
infections
bleeding disorders
|
|
gptkbp:has_color
|
gptkb:Philadelphia_chromosome
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Philadelphia chromosome-positive leukemia
|
|
gptkbp:is_associated_with
|
CML
ALL
|
|
gptkbp:is_characterized_by
|
chromosomal translocation
abnormal cell proliferation
|
|
gptkbp:is_considered
|
a type of cancer
|
|
gptkbp:is_linked_to
|
poor response to standard chemotherapy
|
|
gptkbp:is_monitored_by
|
PCR testing
|
|
gptkbp:is_often_used_in
|
gptkb:Person
adults
men
|
|
gptkbp:is_popular_in
|
approximately 15-30% of adult acute lymphoblastic leukemia cases
|
|
gptkbp:is_studied_in
|
clinical research
|
|
gptkbp:is_used_for
|
night sweats
lymphadenopathy
pallor
|
|
gptkbp:recognizes
|
cytogenetic analysis
FISH analysis
|
|
gptkbp:requires
|
regular monitoring
stem cell transplant
|
|
gptkbp:risk_factor
|
exposure to radiation
certain genetic disorders
|
|
gptkbp:social_responsibility
|
bone marrow biopsy
|
|
gptkbp:symptoms
|
fatigue
weight loss
fever
|
|
gptkbp:treatment
|
gptkb:imatinib
gptkb:dasatinib
gptkb:nilotinib
tyrosine kinase inhibitors
remission
hematologist
eradication of leukemic cells
|