Philadelphia chromosome-positive leukemia
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
leukemia
|
| gptkbp:abbreviation |
Ph+ leukemia
|
| gptkbp:affects |
hematopoietic system
|
| gptkbp:characteristic |
uncontrolled cell proliferation
abnormal white blood cells |
| gptkbp:hasAbnormality |
gptkb:Philadelphia_chromosome
|
| gptkbp:hasDiagnosticMethod |
gptkb:FISH
PCR karyotyping |
| gptkbp:hasEpidemiology |
more common in adults
rare in children |
| gptkbp:hasGeneticTranslocation |
t(9;22)(q34;q11)
|
| https://www.w3.org/2000/01/rdf-schema#label |
Philadelphia chromosome-positive leukemia
|
| gptkbp:ICD-10_code |
C92.1
|
| gptkbp:involvedIn |
gptkb:ABL1
gptkb:BCR |
| gptkbp:OMIM |
608232
|
| gptkbp:producesFusionProtein |
gptkb:BCR-ABL
|
| gptkbp:prognosis |
variable
|
| gptkbp:subspecies |
gptkb:chronic_myeloid_leukemia
leukemia |
| gptkbp:treatment |
gptkb:receptor_tyrosine_kinase
gptkb:dasatinib gptkb:imatinib gptkb:nilotinib stem cell transplantation |
| gptkbp:bfsParent |
gptkb:Sprycel
gptkb:BCR gptkb:BCR-ABL_tyrosine_kinase |
| gptkbp:bfsLayer |
7
|