|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CREB2
CREB-2
CREB2L
TXREB
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
metabolic disorders
|
|
gptkbp:binds
|
CRE (cAMP response element)
|
|
gptkbp:discoveredBy
|
M. Hai et al.
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:Entrez_Gene_ID
|
468
ENSG00000128272
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsHeterodimerWith
|
gptkb:ATF3
gptkb:ATF6
C/EBP family proteins
|
|
gptkbp:fullName
|
Activating Transcription Factor 4
|
|
gptkbp:function
|
gptkb:transcription_factor
regulation of gene expression in response to stress
|
|
gptkbp:gene
|
gptkb:ATF4
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:785
|
|
gptkbp:length
|
351 amino acids
|
|
gptkbp:locatedOnChromosome
|
22
|
|
gptkbp:location
|
gptkb:22q13.1
|
|
gptkbp:molecularWeight
|
38 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Atf4
|
|
gptkbp:PDB
|
2DGC
|
|
gptkbp:phosphorylates
|
PERK pathway
GCN2 pathway
HRI pathway
PKR pathway
|
|
gptkbp:regulates
|
gptkb:integrated_stress_response
gptkb:cellular_stress_response
apoptosis
unfolded protein response
amino acid metabolism
oxidative stress response
upregulated by stress
downregulated in normal conditions
|
|
gptkbp:relatedTo
|
ER stress
amino acid starvation
integrated stress response pathway
|
|
gptkbp:UniProtID
|
P18848
|
|
gptkbp:bfsParent
|
gptkb:ATF_family
gptkb:DDIT3
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATF4
|