Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
gptkb:CREB2
CREB-2 CREB2L TXREB |
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases metabolic disorders |
| gptkbp:binds |
CRE (cAMP response element)
|
| gptkbp:discoveredBy |
M. Hai et al.
|
| gptkbp:discoveredIn |
1989
|
| gptkbp:Entrez_Gene_ID |
468
ENSG00000128272 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:formsHeterodimerWith |
gptkb:ATF3
gptkb:ATF6 C/EBP family proteins |
| gptkbp:fullName |
Activating Transcription Factor 4
|
| gptkbp:function |
transcription factor
regulation of gene expression in response to stress |
| gptkbp:gene |
gptkb:ATF4
|
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
HGNC:785
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATF4
|
| gptkbp:length |
351 amino acids
|
| gptkbp:locatedOnChromosome |
22
|
| gptkbp:location |
gptkb:22q13.1
|
| gptkbp:molecularWeight |
38 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Atf4
|
| gptkbp:PDB |
2DGC
|
| gptkbp:phosphorylates |
PERK pathway
GCN2 pathway HRI pathway PKR pathway |
| gptkbp:regulates |
gptkb:integrated_stress_response
apoptosis unfolded protein response amino acid metabolism oxidative stress response cellular stress response upregulated by stress downregulated in normal conditions |
| gptkbp:relatedTo |
ER stress
amino acid starvation integrated stress response pathway |
| gptkbp:UniProtID |
P18848
|
| gptkbp:bfsParent |
gptkb:ATF_family
gptkb:DDIT3 |
| gptkbp:bfsLayer |
7
|