Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cellular stress response
|
| gptkbp:activatedBy |
gptkb:virus
oxidative stress endoplasmic reticulum stress cellular stress amino acid deprivation |
| gptkbp:alsoKnownAs |
gptkb:ISR
|
| gptkbp:cause |
global translation attenuation
selective translation of ATF4 |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases metabolic disorders |
| https://www.w3.org/2000/01/rdf-schema#label |
integrated stress response
|
| gptkbp:involves |
gptkb:HRI
gptkb:PERK PKR phosphorylation of eIF2α GCN2 eIF2α kinases |
| gptkbp:regulates |
apoptosis
cell survival metabolism protein synthesis autophagy |
| gptkbp:studiedIn |
gptkb:yeast
mammalian cells |
| gptkbp:bfsParent |
gptkb:DDIT3
|
| gptkbp:bfsLayer |
7
|