|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CREB2
CAMP-responsive element-binding protein 2
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
neurodegenerative disease
|
|
gptkbp:binds
|
gptkb:cAMP_response_element_(CRE)
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:encodedBy
|
ATF3 gene
|
|
gptkbp:Entrez_Gene_ID
|
467
ENSG00000162772
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Activating Transcription Factor 3
|
|
gptkbp:function
|
transcription factor
regulation of gene expression
apoptosis regulation
cellular stress response
immune response modulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
785
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATF3
|
|
gptkbp:inducedBy
|
cellular stress
|
|
gptkbp:interactsWith
|
gptkb:JUN
gptkb:FOS
other ATF family members
|
|
gptkbp:length
|
181 amino acids (human)
|
|
gptkbp:locatedOnChromosome
|
chromosome 1q32.3
|
|
gptkbp:modulatedBy
|
cell differentiation
cell proliferation
cell survival
immune cell activation
|
|
gptkbp:molecularWeight
|
20 kDa (approximate)
|
|
gptkbp:OMIM
|
600732
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:entomologist
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
2L0S
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:proteinFamily
|
gptkb:ATF/CREB_family
|
|
gptkbp:regulates
|
cell cycle genes
apoptosis-related genes
downregulated in some cancers
inflammatory response genes
upregulated by stress signals
|
|
gptkbp:structure
|
contains basic leucine zipper (bZIP) domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
P18847
|
|
gptkbp:bfsParent
|
gptkb:ATF_family
|
|
gptkbp:bfsLayer
|
7
|