|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:CHOP
gptkb:C/EBP_zeta
gptkb:GADD153
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:myxoid_liposarcoma
|
|
gptkbp:biologicalProcess
|
apoptotic process
negative regulation of cell proliferation
DNA binding
cellular response to stress
transcriptional regulation
response to unfolded protein
|
|
gptkbp:encodes
|
gptkb:DNA_damage-inducible_transcript_3_protein
|
|
gptkbp:Entrez_Gene_ID
|
1649
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
2736
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DDIT3
|
|
gptkbp:interactsWith
|
gptkb:ATF4
gptkb:C/EBP_beta
gptkb:FUS-DDIT3_fusion_protein
|
|
gptkbp:involvedIn
|
apoptosis
endoplasmic reticulum stress response
|
|
gptkbp:length
|
4 exons
|
|
gptkbp:locatedOnChromosome
|
12q13.3
|
|
gptkbp:memberOf
|
gptkb:C/EBP_family
|
|
gptkbp:mutationAssociatedWith
|
fusion with FUS or EWSR1 leads to oncogenic transformation
|
|
gptkbp:OMIM
|
603153
|
|
gptkbp:orthologInMouse
|
gptkb:Ddit3
|
|
gptkbp:pathway
|
gptkb:integrated_stress_response
gptkb:unfolded_protein_response_(UPR)
PERK-mediated pathway
|
|
gptkbp:proteinFamily
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:regulates
|
cell differentiation
cell cycle arrest
induced by DNA damage
induced by ER stress
regulated by ATF4
regulated by PERK pathway
acts as dominant-negative inhibitor of C/EBP family
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:translocationPartner
|
gptkb:FUS
gptkb:EWSR1
|
|
gptkbp:UniProtID
|
P35638
|
|
gptkbp:bfsParent
|
gptkb:Fused_in_Sarcoma
|
|
gptkbp:bfsLayer
|
6
|