|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:AICAR
gptkb:metformin
gptkb:AMP
gptkb:ADP
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:component
|
AMPK complex
|
|
gptkbp:EC_number
|
2.7.11.31
|
|
gptkbp:encodedBy
|
gptkb:PRKAA1_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000132356
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:AMP-activated_protein_kinase_catalytic_subunit_alpha-1
|
|
gptkbp:function
|
catalytic subunit of AMP-activated protein kinase (AMPK)
|
|
gptkbp:gene
|
gptkb:PRKAA1
|
|
gptkbp:GOID
|
gptkb:GO:0004674
GO:0005524
GO:0006468
|
|
gptkbp:HGNC_ID
|
9381
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AMPKA1
|
|
gptkbp:inhibitedBy
|
gptkb:compound_C
|
|
gptkbp:interactsWith
|
gptkb:AXIN1
gptkb:LKB1
AMPKB1
AMPKG1
|
|
gptkbp:involvedIn
|
cellular energy homeostasis
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q31.1
|
|
gptkbp:molecularWeight
|
~63 kDa
|
|
gptkbp:OMIM
|
602739
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Rattus norvegicus (rat)
|
|
gptkbp:PDB
|
gptkb:4CFE
4CFF
4C0O
|
|
gptkbp:phosphorylates
|
gptkb:CaMKKβ
gptkb:LKB1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:refSeqID
|
NP_002721.2
|
|
gptkbp:regulates
|
metabolic pathways
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequence
|
559 amino acids
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q13131
|
|
gptkbp:bfsParent
|
gptkb:PRKAA1_gene
|
|
gptkbp:bfsLayer
|
8
|