AMP-activated protein kinase catalytic subunit alpha-1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	gptkb:AICAR gptkb:metformin gptkb:AMP gptkb:ADP
gptkbp:alternativeName	gptkb:AMPK_alpha-1 gptkb:AMPK_catalytic_subunit_alpha-1 PRKAA1 protein
gptkbp:associatedWith	gptkb:cancer gptkb:type_2_diabetes obesity
gptkbp:biologicalProcess	protein serine/threonine kinase activity
gptkbp:component	gptkb:AMP-activated_protein_kinase_(AMPK)_complex
gptkbp:Entrez_Gene_ID	ENSG00000132356
gptkbp:expressedIn	gptkb:skeletal_muscle brain heart liver
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	regulation of cellular energy homeostasis catalytic subunit of AMPK
gptkbp:gene	gptkb:PRKAA1
https://www.w3.org/2000/01/rdf-schema#label	AMP-activated protein kinase catalytic subunit alpha-1
gptkbp:inhibitedBy	gptkb:ATP
gptkbp:interactsWith	AMPK beta subunit AMPK gamma subunit
gptkbp:involves	AMPK signaling pathway
gptkbp:length	548
gptkbp:locatedOnChromosome	gptkb:chromosome_5
gptkbp:molecularWeight	63 kDa
gptkbp:OMIM	602739
gptkbp:orthologInMouse	gptkb:Prkaa1
gptkbp:PDB	gptkb:4CFE 4RED
gptkbp:phosphorylates	gptkb:CaMKKβ gptkb:LKB1
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:RefSeq	NM_006251
gptkbp:regulates	glucose uptake autophagy fatty acid oxidation mTOR signaling
gptkbp:subunit	AMPK heterotrimeric complex
gptkbp:UniProtID	gptkb:Q13131
gptkbp:bfsParent	gptkb:PRKAA1
gptkbp:bfsLayer	7