AMP-activated protein kinase
GPTKB entity
Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:George_Hardie
|
| gptkbp:associated_with |
chronic diseases
metabolic syndrome obesity cardiovascular diseases insulin resistance type 2 diabetes |
| gptkbp:community |
mitochondrial biogenesis
|
| gptkbp:composed_of |
catalytic subunit
regulatory subunit |
| gptkbp:enhances |
gluconeogenesis
|
| gptkbp:established |
gptkb:ATP
gptkb:stadium nutrient availability AMP caloric restriction lipogenesis exercise-induced signals |
| gptkbp:function |
regulates energy balance
|
| gptkbp:has_role |
gptkb:psychologist
immune response metabolic adaptation cellular energy homeostasis exercise adaptation |
| https://www.w3.org/2000/01/rdf-schema#label |
AMP-activated protein kinase
|
| gptkbp:influences |
cellular metabolism
cellular stress response cellular proliferation insulin sensitivity cellular differentiation fat metabolism cellular signaling pathways glucose homeostasis fatty acid metabolism metabolic flexibility |
| gptkbp:interacts_with |
gptkb:m_TOR
gptkb:ACC Ca MK Kβ LK B1 |
| gptkbp:is_found_in |
eukaryotic cells
|
| gptkbp:is_involved_in |
lipid metabolism
metabolic pathways thermogenesis neuroprotection autophagy aging processes cancer metabolism muscle metabolism hypoxia response cell growth regulation stress response pathways energy sensing |
| gptkbp:regulates |
apoptosis
cellular homeostasis cellular respiration glucose metabolism protein synthesis inflammation fatty acid oxidation oxidative stress cholesterol synthesis glucose uptake cellular energy production hormonal signaling |