AMP-activated protein kinase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:abbreviation	gptkb:AMPK
gptkbp:activatedBy	gptkb:AMP gptkb:ADP
gptkbp:composedOf	alpha subunit beta subunit gamma subunit
gptkbp:discoveredBy	gptkb:D._Grahame_Hardie
gptkbp:discoveredIn	1980s
gptkbp:EC_number	2.7.11.31
gptkbp:foundIn	eukaryotes
gptkbp:function	regulation of cellular energy homeostasis
gptkbp:gene	gptkb:PRKAA1 gptkb:PRKAA2 gptkb:PRKAB1 gptkb:PRKAB2 gptkb:PRKAG1 gptkb:PRKAG2 gptkb:PRKAG3
https://www.w3.org/2000/01/rdf-schema#label	AMP-activated protein kinase
gptkbp:inhibitedBy	gptkb:ATP
gptkbp:involvedIn	gptkb:cancer gptkb:type_2_diabetes obesity exercise response response to metabolic stress
gptkbp:locatedIn	gptkb:nucleus gptkb:cytoplasm
gptkbp:orthologIn	gptkb:plant_SnRK1 gptkb:yeast_SNF1
gptkbp:phosphorylates	gptkb:HMG-CoA_reductase gptkb:TSC2 gptkb:acetyl-CoA_carboxylase
gptkbp:regulates	gptkb:mTOR_pathway lipid metabolism cell growth glucose uptake protein synthesis autophagy cell polarity fatty acid oxidation mitochondrial biogenesis cholesterol synthesis glycogen synthesis
gptkbp:target	gptkb:AICAR gptkb:metformin gptkb:thiazolidinediones
gptkbp:UniProtID	gptkb:Q13131
gptkbp:bfsParent	gptkb:DB00740 gptkb:AMPK gptkb:DB00783 gptkb:DB00303 gptkb:DB00170
gptkbp:bfsLayer	6