DB00740

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1957
1994
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:CASNumber 657-24-9
gptkbp:color white
gptkbp:contraindication metabolic acidosis
renal impairment
gptkbp:drugClass biguanide
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:hasBoxedWarning lactic acidosis
gptkbp:hasCommonBrandName gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:hasEssentialMedicineStatus gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:hasFirstApprovalCountry gptkb:France
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB00740
gptkbp:indication gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkbp:legalStatus prescription only
off-patent
gptkbp:manufacturer various generic manufacturers
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
gptkbp:meltingPoint 223-226°C
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding <20%
gptkbp:PubChem_CID gptkb:DB00740
gptkb:CHEMBL1431
gptkb:D01841
4091
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
gastrointestinal upset
lactic acidosis
gptkbp:solubility freely soluble in water
gptkbp:synonym gptkb:Glucophage
gptkb:Metformina
gptkb:Metformine
gptkb:Metforminum
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkbp:bfsParent gptkb:riluzole
gptkbp:bfsLayer 5