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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Argonaute
AGO
|
|
gptkbp:binds
|
gptkb:siRNA
non-coding RNA
small RNA
|
|
gptkbp:component
|
gptkb:RNA-induced_silencing_complex
|
|
gptkbp:domain
|
PAZ domain
PIWI domain
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
prokaryotes
eukaryotes
|
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gptkbp:fullName
|
gptkb:Argonaute_protein
|
|
gptkbp:function
|
RNA silencing
gene regulation
|
|
gptkbp:hasBiologicalActivity
|
endoribonuclease
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AGO protein
|
|
gptkbp:involvedIn
|
transcriptional gene silencing
post-transcriptional gene silencing
|
|
gptkbp:mechanismOfAction
|
cleaves target mRNA
promotes mRNA decay
represses translation
|
|
gptkbp:namedAfter
|
Argonaute mutant phenotype in Arabidopsis
|
|
gptkbp:orthologIn
|
gptkb:AGO1
gptkb:AGO2
gptkb:AGO3
gptkb:PIWI_proteins
AGO4
|
|
gptkbp:PDB
|
1YTU
4EI3
4W5O
|
|
gptkbp:proteinFamily
|
Argonaute family
|
|
gptkbp:relatedTo
|
gptkb:RNA_interference
gene silencing
piRNA pathway
microRNA pathway
|
|
gptkbp:structure
|
bilobal
|
|
gptkbp:studiedIn
|
gptkb:Homo_sapiens
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkb:Arabidopsis_thaliana
|
|
gptkbp:bfsParent
|
gptkb:Argonaute
|
|
gptkbp:bfsLayer
|
8
|