Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
piRNA pathway
|
| gptkbp:binds |
piRNAs
|
| gptkbp:discoveredIn |
gptkb:Drosophila_melanogaster
|
| gptkbp:domain |
PAZ domain
PIWI domain |
| gptkbp:expressedIn |
gptkb:testis
|
| gptkbp:firstDescribed |
1997
|
| gptkbp:foundIn |
animals
|
| gptkbp:function |
gene silencing
transposon silencing |
| https://www.w3.org/2000/01/rdf-schema#label |
PIWI proteins
|
| gptkbp:interactsWith |
Tudor domain proteins
|
| gptkbp:involvedIn |
gptkb:RNA_interference
transcriptional gene silencing post-transcriptional gene silencing |
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:mutationAssociatedWith |
sterility in Drosophila
|
| gptkbp:namedAfter |
P-element Induced Wimpy testis
|
| gptkbp:orthologIn |
fungi
mammals plants HILI HIWI MILI MIWI PIWIL1 PIWIL2 PIWIL3 PIWIL4 |
| gptkbp:regulates |
transposable elements
|
| gptkbp:relatedTo |
stem cell maintenance
genome integrity |
| gptkbp:role |
DNA methylation
histone modification epigenetic regulation spermatogenesis chromatin remodeling RNA cleavage oogenesis germline development piRNA biogenesis protection of germline genome transgenerational epigenetic inheritance transposon repression |
| gptkbp:subclassOf |
Argonaute proteins
|
| gptkbp:bfsParent |
gptkb:Argonaute
gptkb:Argonaute_protein |
| gptkbp:bfsLayer |
8
|