|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Argonaute-2
EIF2C2
hAgo2
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurological disorders
|
|
gptkbp:biologicalProcess
|
RNA binding
endonuclease activity
|
|
gptkbp:discoveredBy
|
Gregory J. Hannon group
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:domain
|
N-terminal domain
PAZ domain
PIWI domain
MID domain
|
|
gptkbp:encodedBy
|
AGO2 gene
|
|
gptkbp:Entrez_Gene_ID
|
27161
ENSG00000123908
|
|
gptkbp:family
|
Argonaute family
|
|
gptkbp:fullName
|
Argonaute RISC catalytic component 2
|
|
gptkbp:function
|
RNA silencing
cleavage of target mRNA
component of RISC complex
|
|
gptkbp:gene
|
gptkb:AGO2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AGO2
|
|
gptkbp:interactsWith
|
gptkb:GW182
gptkb:TRBP
miRNAs
siRNAs
DICER1
|
|
gptkbp:involvedIn
|
gptkb:RNA_interference
microRNA-mediated gene silencing
siRNA-mediated gene silencing
|
|
gptkbp:length
|
859 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.3
|
|
gptkbp:location
|
gptkb:P-bodies
gptkb:cytoplasm
|
|
gptkbp:OMIM
|
606229
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Arabidopsis_thaliana
|
|
gptkbp:PDB
|
4EI3
4W5O
4OLA
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_012154
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:subunit
|
gptkb:RNA-induced_silencing_complex_(RISC)
|
|
gptkbp:UniProtID
|
Q9UKV8
|
|
gptkbp:bfsParent
|
gptkb:Dicer1
gptkb:Dicer_protein
gptkb:Argonaute
gptkb:Dicer
gptkb:Argonaute_protein
|
|
gptkbp:bfsLayer
|
8
|