|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:siRNA
non-coding RNA
small RNA molecules
|
|
gptkbp:discoveredIn
|
gptkb:Arabidopsis_thaliana
|
|
gptkbp:domain
|
PAZ domain
PIWI domain
|
|
gptkbp:encodedBy
|
AGO genes
|
|
gptkbp:firstDescribed
|
2001
|
|
gptkbp:foundIn
|
prokaryotes
eukaryotes
|
|
gptkbp:function
|
gptkb:RNA_interference
gene silencing
|
|
gptkbp:GO_term
|
GO:0035195 (gene silencing by miRNA)
GO:0035194 (gene silencing by siRNA)
|
|
gptkbp:hasBiologicalActivity
|
endoribonuclease (slicer activity)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Argonaute protein
|
|
gptkbp:interactsWith
|
gptkb:RNA-induced_silencing_complex_(RISC)
gptkb:Dicer
|
|
gptkbp:involvedIn
|
chromatin modification
translational repression
post-transcriptional gene silencing
mRNA cleavage
|
|
gptkbp:namedAfter
|
Argonaute (mythological ship)
|
|
gptkbp:orthologIn
|
gptkb:AGO1
gptkb:AGO2
gptkb:AGO3
gptkb:PIWI_proteins
animals
humans
plants
AGO4
|
|
gptkbp:PDB
|
1YTU
|
|
gptkbp:requires
|
microRNA function
siRNA function
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Molecular_Cell_Biology
Cell
|
|
gptkbp:role
|
stem cell maintenance
epigenetic regulation
developmental regulation
antiviral defense
transposon silencing
germline development
|
|
gptkbp:structure
|
bilobal
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q9UL18 (human AGO2)
|
|
gptkbp:bfsParent
|
gptkb:RNA-induced_silencing_complex
|
|
gptkbp:bfsLayer
|
7
|