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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Endoribonuclease_Dicer
Ribonuclease III-like protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gene silencing
developmental processes
|
|
gptkbp:biologicalProcess
|
endoribonuclease activity
|
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gptkbp:discoveredBy
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gptkb:Gregory_J._Hannon
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|
gptkbp:discoveredIn
|
2001
|
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gptkbp:domain
|
helicase domain
PAZ domain
RNase III domain
|
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gptkbp:encodedBy
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gptkb:DICER1_gene
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gptkbp:foundIn
|
eukaryotes
|
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gptkbp:function
|
gptkb:RNA_interference
microRNA processing
siRNA processing
|
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gptkbp:GO_term
|
GO:0031050
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dicer protein
|
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gptkbp:interactsWith
|
gptkb:PACT
gptkb:AGO2
gptkb:TRBP
|
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gptkbp:locale
|
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
14q32.13 (human)
|
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gptkbp:mutationAssociatedWith
|
gptkb:Wilms_tumor
gptkb:pleuropulmonary_blastoma
gptkb:DICER1_syndrome
|
|
gptkbp:OMIM
|
606241
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:product
|
small interfering RNA
non-coding RNA
|
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gptkbp:regulates
|
gene expression
|
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gptkbp:requires
|
microRNA biogenesis
RNA-induced silencing complex loading
|
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gptkbp:structure
|
multi-domain protein
|
|
gptkbp:substrate
|
double-stranded RNA
pre-microRNA
|
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gptkbp:UniProtID
|
Q9UPY3
|
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gptkbp:bfsParent
|
gptkb:DICER1_gene
gptkb:DICER1_syndrome
|
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gptkbp:bfsLayer
|
7
|