|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:Endoribonuclease_Dicer
Helicase with RNase motif protein
|
|
gptkbp:associatedWith
|
gptkb:DICER1_syndrome
tumor predisposition
|
|
gptkbp:biologicalProcess
|
endoribonuclease activity
|
|
gptkbp:component
|
GO:0005829 (cytosol)
|
|
gptkbp:discoveredBy
|
gptkb:Gregory_J._Hannon
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:domain
|
helicase domain
PAZ domain
RNase III domain
dsRBD domain
|
|
gptkbp:encodedBy
|
gptkb:DICER1_gene
|
|
gptkbp:enzymeClassification
|
ribonuclease III
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:RNA_interference
microRNA processing
small interfering RNA processing
GO:0004525 (ribonuclease III activity)
|
|
gptkbp:GOProcess
|
GO:0031053 (small RNA mediated gene silencing)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dicer1
|
|
gptkbp:interactsWith
|
gptkb:PACT
gptkb:AGO2
gptkb:TRBP
|
|
gptkbp:length
|
1922 amino acids
|
|
gptkbp:locatedOnChromosome
|
14q32.13
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
218 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Wilms_tumor
gptkb:Sertoli-Leydig_cell_tumor
gptkb:cystic_nephroma
gptkb:pineoblastoma
gptkb:pleuropulmonary_blastoma
gptkb:rhabdomyosarcoma
germline mutation
somatic mutation
cancer risk
multinodular goiter
ciliary body medulloepithelioma
nasal chondromesenchymal hamartoma
ovarian sex cord-stromal tumor
pituitary blastoma
thyroid gland neoplasm
|
|
gptkbp:OMIM
|
606241
|
|
gptkbp:orthologIn
|
Dicer (Drosophila melanogaster)
|
|
gptkbp:regulates
|
gene expression
heterochromatin formation
transposon silencing
|
|
gptkbp:requires
|
embryonic development
stem cell maintenance
|
|
gptkbp:UniProtID
|
Q9UPY3
|
|
gptkbp:bfsParent
|
gptkb:DICER1_gene
|
|
gptkbp:bfsLayer
|
7
|