|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:ACE2_receptor
|
|
gptkbp:cleavage
|
furin protease
|
|
gptkbp:contains
|
gptkb:receptor-binding_domain_(RBD)
|
|
gptkbp:contributedTo
|
immune evasion
viral infectivity
host range
|
|
gptkbp:encodedBy
|
gptkb:S_gene
|
|
gptkbp:exposedBy
|
gptkb:viral_envelope
|
|
gptkbp:foundIn
|
gptkb:COVID-19
|
|
gptkbp:fullName
|
spike glycoprotein
|
|
gptkbp:function
|
mediates viral entry into host cells
|
|
gptkbp:glycosylation
|
heavily glycosylated
|
|
gptkbp:interactsWith
|
gptkb:TMPRSS2
host cell membrane
|
|
gptkbp:length
|
~1273 amino acids (SARS-CoV-2)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:D614G
gptkb:P681R
gptkb:E484K
gptkb:N501Y
|
|
gptkbp:presentIn
|
gptkb:COVID-19
gptkb:MERS-CoV
gptkb:SARS-CoV
|
|
gptkbp:role
|
membrane fusion
host cell recognition
|
|
gptkbp:structure
|
trimeric
|
|
gptkbp:subunit
|
S1
S2
|
|
gptkbp:target
|
gptkb:COVID-19_vaccines
neutralizing antibodies
|
|
gptkbp:usedIn
|
diagnostic tests
serological assays
vaccine design
|
|
gptkbp:visualizes
|
cryo-electron microscopy
|
|
gptkbp:bfsParent
|
gptkb:S-tag
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
S-protein
|