|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Tangier_disease
cystic fibrosis
drug resistance in cancer
|
|
gptkbp:discoveredBy
|
gptkb:Julian_Davies
|
|
gptkbp:example
|
gptkb:ABCC1
gptkb:MRP1
gptkb:ABCB1
gptkb:P-glycoprotein
gptkb:TAP1
gptkb:CFTR
gptkb:ABCA1
gptkb:ABCG2
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:fullName
|
ATP-binding cassette transporters
|
|
gptkbp:function
|
transport various molecules across membranes
|
|
gptkbp:GO_term
|
GO:0042626
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABC transporters
|
|
gptkbp:inhibitedBy
|
gptkb:tariquidar
gptkb:verapamil
cyclosporin A
|
|
gptkbp:mechanismOfAction
|
active transport
|
|
gptkbp:numberOfGenes
|
48
|
|
gptkbp:OMIM
|
601107
|
|
gptkbp:powerSource
|
ATP hydrolysis
|
|
gptkbp:proteinFamily
|
gptkb:ABCD
gptkb:ABCE
gptkb:ABCF
gptkb:ABCG
gptkb:ABCC
gptkb:ABCA
ABCB
|
|
gptkbp:publicTransit
|
primary active transport
|
|
gptkbp:relatedTo
|
gptkb:solute_carrier_family
membrane transport proteins
|
|
gptkbp:role
|
lipid transport
toxin secretion
multidrug resistance
antigen presentation
cholesterol transport
|
|
gptkbp:structure
|
nucleotide-binding domains
transmembrane domains
|
|
gptkbp:studiedIn
|
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
gptkb:Bacteria
|
|
gptkbp:UniProtID
|
KW-0005
|
|
gptkbp:bfsParent
|
gptkb:P-loop_NTPase_superfamily
gptkb:Walker_A_motif
|
|
gptkbp:bfsLayer
|
7
|