|
gptkbp:instanceOf
|
gptkb:drug
anti-inflammatory agent
sulfonamide
|
|
gptkbp:administeredBy
|
food (to reduce GI upset)
|
|
gptkbp:ATCCode
|
A07EC01
|
|
gptkbp:bioavailability
|
10-30%
|
|
gptkbp:CASNumber
|
599-79-1
|
|
gptkbp:cause
|
gptkb:anemia
hepatitis
hypersensitivity reactions
agranulocytosis
|
|
gptkbp:chemicalFormula
|
C18H14N4O5S
|
|
gptkbp:color
|
yellow-orange
|
|
gptkbp:contraindication
|
porphyria
sulfa allergy
|
|
gptkbp:discoveredBy
|
Nanna Svartz
|
|
gptkbp:discoveredIn
|
1938
|
|
gptkbp:drugInteraction
|
gptkb:warfarin
gptkb:methotrexate
gptkb:digoxin
folic acid
|
|
gptkbp:eliminationHalfLife
|
5-10 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
sulfasalazine
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mayStain
|
urine yellow-orange
|
|
gptkbp:mechanismOfAction
|
inhibits prostaglandin synthesis
immunomodulatory effects
|
|
gptkbp:meltingPoint
|
> 200°C
|
|
gptkbp:MeSH_ID
|
D013285
|
|
gptkbp:metabolism
|
sulfapyridine
5-aminosalicylic acid
|
|
gptkbp:monitors
|
liver function tests
complete blood count
renal function
|
|
gptkbp:partOf
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:pregnancyCategory
|
C (US)
B2 (Australia)
|
|
gptkbp:proteinBinding
|
99%
|
|
gptkbp:PubChem_CID
|
5339
DB00795
|
|
gptkbp:reducesAbsorptionOf
|
folic acid
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
headache
rash
reversible oligospermia
|
|
gptkbp:solubility
|
practically insoluble in water
|
|
gptkbp:synonym
|
Azulfidine
|
|
gptkbp:UNII
|
4Q81I59GXC
|
|
gptkbp:usedFor
|
gptkb:Crohn's_disease
ulcerative colitis
rheumatoid arthritis
|
|
gptkbp:bfsParent
|
gptkb:Sulfonamides
|
|
gptkbp:bfsLayer
|
6
|