multidrug resistance protein
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:MDR1
gptkb:P-glycoprotein |
| gptkbp:associatedWith |
multidrug resistance
|
| gptkbp:discoveredIn |
1976
|
| gptkbp:encodedBy |
gptkb:ABCB1_gene
|
| gptkbp:foundIn |
gptkb:human
gptkb:Bacteria cancer cells |
| gptkbp:function |
transports drugs across cell membranes
|
| https://www.w3.org/2000/01/rdf-schema#label |
multidrug resistance protein
|
| gptkbp:inhibitedBy |
gptkb:verapamil
cyclosporin A accumulation of chemotherapeutic agents |
| gptkbp:mechanismOfAction |
ATP-dependent efflux pump
|
| gptkbp:memberOf |
gptkb:ATP-binding_cassette_transporter_family
|
| gptkbp:significance |
chemotherapy resistance
|
| gptkbp:structure |
transmembrane protein
|
| gptkbp:studiedIn |
gptkb:pharmacy
oncology |
| gptkbp:target |
drug development
|
| gptkbp:bfsParent |
gptkb:ATP-binding_cassette_sub-family_C_member_1
gptkb:MRP7 gptkb:Major_Facilitator_Superfamily_(MFS) gptkb:CD338 gptkb:P08138 gptkb:ABCG2 |
| gptkbp:bfsLayer |
8
|