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gptkbp:instanceOf
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gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
OPRS1
sigma non-opioid intracellular receptor 1
sigma-1R
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|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
gptkb:ALS_(amyotrophic_lateral_sclerosis)
peripheral neuropathy
|
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gptkbp:binds
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gptkb:fluvoxamine
gptkb:dextromethorphan
gptkb:haloperidol
gptkb:psychostimulants
cocaine
antipsychotics
neurosteroids
antidepressants
pentazocine
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:encodedBy
|
SIGMAR1 gene
|
|
gptkbp:enemyOf
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gptkb:haloperidol
BD1047
BD1063
NE-100
PRE-084
SA4503
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
modulation of ion channels
chaperone activity
regulation of calcium signaling
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
sigma-1 receptor
|
|
gptkbp:involves
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gptkb:depression
schizophrenia
drug addiction
neurodegenerative diseases
pain modulation
|
|
gptkbp:locatedIn
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gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9p13
|
|
gptkbp:modulatedBy
|
gptkb:potassium_channels
gptkb:NMDA_receptor
serotonergic signaling
dopaminergic signaling
voltage-gated calcium channels
glutamatergic signaling
|
|
gptkbp:OMIM
|
601978
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
5HK1
|
|
gptkbp:regulates
|
apoptosis
cell survival
neurite outgrowth
oxidative stress response
|
|
gptkbp:structure
|
single transmembrane domain
223 amino acids (human)
|
|
gptkbp:UniProtID
|
Q99720
|
|
gptkbp:bfsParent
|
gptkb:N,N-Dimethyltryptamine
gptkb:DMT_(N,N-Dimethyltryptamine)
|
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gptkbp:bfsLayer
|
8
|