|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:bone
gptkb:type_2_diabetes
|
|
gptkbp:binds
|
gptkb:Wnt_proteins
frizzled receptors
|
|
gptkbp:discoveredBy
|
Rattner et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:domain
|
NTR domain
frizzled domain
|
|
gptkbp:encodedBy
|
SFRP4 gene
|
|
gptkbp:Entrez_Gene_ID
|
6424
ENSG00000152583
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:testis
heart
adipose tissue
pancreas
|
|
gptkbp:fullName
|
Secreted frizzled-related protein 4
|
|
gptkbp:function
|
modulates Wnt signaling pathway
|
|
gptkbp:gene
|
gptkb:SFRP4
|
|
gptkbp:HGNC_ID
|
10778
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
sFRP4
|
|
gptkbp:inhibitedBy
|
gptkb:Wnt_signaling
|
|
gptkbp:length
|
346 amino acids
|
|
gptkbp:locatedOnChromosome
|
7p14.1
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
37 kDa
|
|
gptkbp:OMIM
|
605846
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
cell differentiation
apoptosis regulation
bone morphogenesis
|
|
gptkbp:PDB
|
2QVS
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:relatedTo
|
apoptosis
cell proliferation
tumor suppression
bone development
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:UniProtID
|
Q6FHJ7
|
|
gptkbp:bfsParent
|
gptkb:sFRP_proteins
|
|
gptkbp:bfsLayer
|
7
|