|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:Melatonin_receptor_1A
gptkb:Melatonin_receptor_type_1A
|
|
gptkbp:associatedWith
|
insomnia
mood disorders
sleep phase disorders
|
|
gptkbp:binds
|
gptkb:melatonin
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:MTNR1A_gene
|
|
gptkbp:enemyOf
|
gptkb:Luzindole
gptkb:Ramelteon
gptkb:Tasimelteon
gptkb:Agomelatine
|
|
gptkbp:Entrez_Gene_ID
|
4543
|
|
gptkbp:expressedIn
|
gptkb:suprachiasmatic_nucleus
brain
retina
|
|
gptkbp:family
|
gptkb:rhodopsin-like_GPCRs
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
sleep regulation
regulation of circadian rhythms
|
|
gptkbp:HGNC_ID
|
gptkb:MTNR1A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MT1 receptor
|
|
gptkbp:length
|
350 amino acids
|
|
gptkbp:ligand
|
gptkb:melatonin
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
4q35.2
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:OMIM
|
600804
|
|
gptkbp:PDB
|
gptkb:6ME6
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
light exposure
circadian clock
|
|
gptkbp:relatedTo
|
gptkb:MT2_receptor
|
|
gptkbp:speciesHomologs
|
gptkb:livestock
gptkb:mouse
right
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:targetOfDrug
|
gptkb:depression
sleep disorders
|
|
gptkbp:type
|
inhibits adenylate cyclase
decreases cAMP levels
|
|
gptkbp:UniProtID
|
gptkb:P48039
|
|
gptkbp:bfsParent
|
gptkb:Melatonin
|
|
gptkbp:bfsLayer
|
6
|