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gptkbp:instanceOf
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biological pathway
hormone system
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gptkbp:abbreviation
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gptkb:RAS
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gptkbp:activatedBy
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sympathetic nervous system
low blood pressure
low sodium concentration
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gptkbp:component
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gptkb:renin
gptkb:angiotensin-converting_enzyme
gptkb:angiotensin_I
gptkb:angiotensin_II
gptkb:aldosterone
gptkb:angiotensinogen
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gptkbp:discoveredBy
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gptkb:Eduardo_Braun-Menéndez
gptkb:Irvine_Page
gptkb:Leonardo_Rosenfeld
gptkb:Reginald_Smith
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https://www.w3.org/2000/01/rdf-schema#label
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renin-angiotensin system
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gptkbp:influenced
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water retention
cardiac output
vasoconstriction
aldosterone secretion
sodium retention
systemic vascular resistance
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gptkbp:inhibitedBy
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gptkb:angiotensin-converting_enzyme_inhibitors
gptkb:angiotensin_receptor_blockers
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gptkbp:medicalTreatment
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gptkb:aldosterone_antagonists
ACE inhibitors
angiotensin II receptor blockers
direct renin inhibitors
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gptkbp:processor
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conversion of angiotensin I to angiotensin II
vasoconstriction
conversion of angiotensinogen to angiotensin I
feedback inhibition by angiotensin II
increase in blood pressure
increase in sodium reabsorption
increase in water reabsorption
stimulation of aldosterone release
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gptkbp:regulates
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blood pressure
fluid balance
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gptkbp:relatedTo
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heart failure
hypertension
chronic kidney disease
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gptkbp:siteOfAction
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gptkb:adrenal_gland
gptkb:kidney
blood vessels
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gptkbp:bfsParent
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gptkb:angiotensin_receptor
gptkb:renin
gptkb:angiotensin_II
gptkb:ACE_(gene)
gptkb:Angiotensin-converting_enzyme
gptkb:Angiotensin-converting_enzyme_2
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gptkbp:bfsLayer
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6
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