Angiotensin-converting enzyme

URI: https://gptkb.org/entity/Angiotensin-converting_enzyme
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:ACE
gptkbp:alternativeName gptkb:kininase_II
gptkb:peptidyl-dipeptidase_A
gptkbp:associatedWith heart failure
hypertension
diabetic nephropathy
gptkbp:cofactor zinc
gptkbp:discoveredBy gptkb:Leonard_T._Skeggs,_Jr.
gptkbp:discoveredIn 1956
gptkbp:EC_number 3.4.15.1
gptkbp:foundIn lungs
kidneys
testes
endothelial cells
gptkbp:function inactivates bradykinin
catalyzes conversion of angiotensin I to angiotensin II
gptkbp:gene gptkb:ACE_gene
https://www.w3.org/2000/01/rdf-schema#label Angiotensin-converting enzyme
gptkbp:inhibitedBy ACE inhibitor
treatment of chronic kidney disease
treatment of heart failure
treatment of hypertension
gptkbp:location_(human) gptkb:chromosome_17q23
gptkbp:molecularWeight ~150 kDa
gptkbp:product gptkb:angiotensin_II
gptkbp:role gptkb:renin-angiotensin_system
regulation of blood pressure
gptkbp:structure gptkb:protein
gptkbp:substrate gptkb:angiotensin_I
gptkbp:UniProtID P12821
gptkbp:bfsParent gptkb:ACE
gptkbp:bfsLayer 5