angiotensin-converting enzyme

URI: https://gptkb.org/entity/angiotensin-converting_enzyme
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:ACE
gptkbp:alternativeName gptkb:kininase_II
gptkb:peptidyl-dipeptidase_A
gptkbp:cofactor zinc
gptkbp:discoveredBy gptkb:Leonard_T._Skeggs
gptkbp:discoveredIn 1956
gptkbp:EC_number 3.4.15.1
gptkbp:function inactivates bradykinin
catalyzes conversion of angiotensin I to angiotensin II
gptkbp:gene gptkb:ACE_gene
https://www.w3.org/2000/01/rdf-schema#label angiotensin-converting enzyme
gptkbp:inhibitedBy ACE inhibitor
gptkbp:locatedOnChromosome gptkb:17q23.3
gptkbp:location gptkb:testis
lungs
kidneys
surface of endothelial cells
gptkbp:molecularWeight ~150 kDa
gptkbp:OMIM 106180
gptkbp:pathway gptkb:renin-angiotensin_system
gptkbp:product gptkb:angiotensin_II
gptkbp:role heart failure
hypertension
diabetic nephropathy
gptkbp:significance target of antihypertensive drugs
gptkbp:structure zinc metallopeptidase
gptkbp:substrate gptkb:angiotensin_I
gptkbp:UniProtID P12821
gptkbp:bfsParent gptkb:angiotensin_II
gptkb:ACE_(gene)
gptkb:Renin-angiotensin_system
gptkb:peptidase_M2_family
gptkbp:bfsLayer 6