angiotensin-converting enzyme inhibitors

URI: https://gptkb.org/entity/angiotensin-converting_enzyme_inhibitors
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:abbreviation ACE inhibitors
gptkbp:approvedBy 1981
gptkbp:category gptkb:antihypertensive_agent
cardiovascular drug
renal protective agent
gptkbp:contraindication pregnancy
bilateral renal artery stenosis
history of angioedema
gptkbp:discoveredBy gptkb:Leonard_T._Skeggs
gptkbp:effect vasodilation
decreased blood pressure
reduced aldosterone secretion
gptkbp:example gptkb:ramipril
gptkb:benazepril
gptkb:trandolapril
gptkb:enalapril
gptkb:captopril
gptkb:lisinopril
fosinopril
moexipril
perindopril
quinapril
gptkbp:excretion gptkb:kidney
gptkbp:interactsWith gptkb:NSAIDs
gptkb:aliskiren
lithium
potassium-sparing diuretics
gptkbp:mechanismOfAction increase bradykinin levels
inhibit angiotensin-converting enzyme
reduce angiotensin II production
gptkbp:metabolism liver
gptkbp:pregnancyCategory D
gptkbp:relatedTo gptkb:aldosterone_antagonists
angiotensin II receptor blockers
renin inhibitors
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect gptkb:angioedema
hypotension
hyperkalemia
dry cough
gptkbp:usedFor heart failure
hypertension
chronic kidney disease
post-myocardial infarction
gptkbp:bfsParent gptkb:renin-angiotensin_system
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label angiotensin-converting enzyme inhibitors