angiotensin-converting enzyme inhibitors
GPTKB entity
Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:abbreviation |
ACE inhibitors
|
| gptkbp:approvedBy |
1981
|
| gptkbp:category |
antihypertensive agent
cardiovascular drug renal protective agent |
| gptkbp:contraindication |
pregnancy
bilateral renal artery stenosis history of angioedema |
| gptkbp:discoveredBy |
gptkb:Leonard_T._Skeggs
|
| gptkbp:effect |
vasodilation
decreased blood pressure reduced aldosterone secretion |
| gptkbp:example |
gptkb:ramipril
gptkb:benazepril gptkb:trandolapril gptkb:enalapril gptkb:captopril gptkb:lisinopril fosinopril moexipril perindopril quinapril |
| gptkbp:excretion |
gptkb:kidney
|
| https://www.w3.org/2000/01/rdf-schema#label |
angiotensin-converting enzyme inhibitors
|
| gptkbp:interactsWith |
gptkb:NSAIDs
gptkb:aliskiren lithium potassium-sparing diuretics |
| gptkbp:mechanismOfAction |
increase bradykinin levels
inhibit angiotensin-converting enzyme reduce angiotensin II production |
| gptkbp:metabolism |
liver
|
| gptkbp:pregnancyCategory |
D
|
| gptkbp:relatedTo |
gptkb:aldosterone_antagonists
angiotensin II receptor blockers renin inhibitors |
| gptkbp:routeOfAdministration |
oral
intravenous |
| gptkbp:sideEffect |
hypotension
hyperkalemia dry cough angioedema |
| gptkbp:usedFor |
heart failure
hypertension chronic kidney disease post-myocardial infarction |
| gptkbp:bfsParent |
gptkb:renin-angiotensin_system
|
| gptkbp:bfsLayer |
7
|