|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:aspartate
serine
histidine
|
|
gptkbp:alternativeName
|
gptkb:EP
gptkb:prolyl_oligopeptidase
PO
|
|
gptkbp:associatedWith
|
neurodegenerative diseases
cognitive functions
|
|
gptkbp:catalyzes
|
hydrolysis of peptide bonds at the carboxyl side of proline residues
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:discoveredBy
|
1971
|
|
gptkbp:EC_number
|
3.4.21.26
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
liver
|
|
gptkbp:family
|
gptkb:S9_family_of_serine_peptidases
|
|
gptkbp:foundIn
|
gptkb:Bacteria
mammals
plants
|
|
gptkbp:gene
|
gptkb:PREP
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
prolyl endopeptidase
|
|
gptkbp:inhibitedBy
|
gptkb:JTP-4819
gptkb:Z-Pro-prolinal
S-17092
|
|
gptkbp:involves
|
peptide hormone processing
neuropeptide metabolism
|
|
gptkbp:locatedIn
|
cytosol
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q22.1
|
|
gptkbp:molecularWeight
|
approximately 80 kDa
|
|
gptkbp:not_active_on
|
large proteins
|
|
gptkbp:PDB
|
gptkb:1E5T
|
|
gptkbp:potential_drug_target_for
|
gptkb:Alzheimer's_disease
gptkb:depression
schizophrenia
cognitive disorders
|
|
gptkbp:structure
|
gptkb:serine_protease
|
|
gptkbp:substrate
|
gptkb:bradykinin
gptkb:vasopressin
gptkb:angiotensin
gptkb:neurotensin
gptkb:thyrotropin-releasing_hormone
gptkb:substance_P
gptkb:oxytocin
short peptides
|
|
gptkbp:UniProtID
|
P48147
|
|
gptkbp:bfsParent
|
gptkb:PEP_family
|
|
gptkbp:bfsLayer
|
6
|