thyrotropin-releasing hormone

URI: https://gptkb.org/entity/thyrotropin-releasing_hormone
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf hormone
peptide
gptkbp:actsOn anterior pituitary gland
gptkbp:administeredBy intravenous injection
gptkbp:alsoKnownAs gptkb:TRH
protirelin
gptkbp:ATCCode H01BA01
gptkbp:CASNumber 24305-27-9
gptkbp:category peptide
hypothalamic hormone
gptkbp:degradedBy TRH-degrading enzyme
gptkbp:discoveredBy gptkb:Roger_Guillemin
gptkb:Andrew_V._Schally
gptkbp:discoveredIn 1969
gptkbp:foundIn brain
gastrointestinal tract
pancreas
gptkbp:halfLife ~5 minutes
gptkbp:hasMolecularFormula C16H22N6O4
https://www.w3.org/2000/01/rdf-schema#label thyrotropin-releasing hormone
gptkbp:MeSH_ID D014285
gptkbp:predecessor prepro-TRH
gptkbp:producedBy hypothalamus
gptkbp:promotion release of prolactin
release of thyroid-stimulating hormone
gptkbp:PubChem_CID 16129618
CHEMBL1201277
gptkbp:recipient TRH receptor
gptkbp:regulates metabolism
thyroid axis
gptkbp:sequence pyroglutamyl-histidyl-proline amide
gptkbp:sideEffect nausea
flushing
urinary urgency
gptkbp:UNII 5Y5F15120W
gptkbp:usedAs diagnostic agent
gptkbp:usedFor testing pituitary function
gptkbp:bfsParent gptkb:prolyl_endopeptidase
gptkb:thyroid-stimulating_hormone
gptkb:lactotroph
gptkb:thyrotroph
gptkbp:bfsLayer 7