Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:prolyl_endopeptidase
gptkb:EP |
| gptkbp:associatedWith |
neurodegenerative diseases
cognitive functions |
| gptkbp:discoveredBy |
1978
|
| gptkbp:EC_number |
3.4.21.26
|
| gptkbp:foundIn |
gptkb:Bacteria
mammals plants |
| gptkbp:function |
cleaves peptide bonds at the carboxyl side of proline residues
|
| gptkbp:gene |
gptkb:PREP
|
| https://www.w3.org/2000/01/rdf-schema#label |
prolyl oligopeptidase
|
| gptkbp:inhibitedBy |
gptkb:JTP-4819
gptkb:Z-Pro-prolinal |
| gptkbp:locatedOnChromosome |
gptkb:6q22.1
|
| gptkbp:location |
cytosol
|
| gptkbp:molecularWeight |
approximately 80 kDa
|
| gptkbp:not_active_on |
large proteins
|
| gptkbp:PDB |
gptkb:1QFS
|
| gptkbp:relatedTo |
gptkb:depression
schizophrenia memory processes |
| gptkbp:structure |
gptkb:serine_protease
|
| gptkbp:substrate |
short proline-containing peptides
|
| gptkbp:UniProtID |
P48147
|
| gptkbp:bfsParent |
gptkb:prolyl_endopeptidase
|
| gptkbp:bfsLayer |
7
|