phosphatase and tensin homolog (PTEN)

URI: https://gptkb.org/entity/phosphatase_and_tensin_homolog_(PTEN)
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alias gptkb:MMAC1
gptkb:TEP1
gptkbp:dephosphorylates gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:discoveredBy gptkb:Peter_C._Steck
gptkbp:discoveredIn 1997
gptkbp:Entrez_Gene_ID gptkb:ENSG00000171862
5728
gptkbp:expressedIn many tissues
gptkbp:function tumor suppressor
phosphatase activity
lipid phosphatase
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 9588
https://www.w3.org/2000/01/rdf-schema#label phosphatase and tensin homolog (PTEN)
gptkbp:inhibitedBy cell proliferation
cell survival
angiogenesis
cell migration
cell adhesion
gptkbp:length 403 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_10
gptkbp:molecularWeight 47 kDa
gptkbp:mutationAssociatedWith gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:cancer
gptkb:Cowden_syndrome
gptkb:endometrial_cancer
gptkb:glioblastoma
prostate cancer
gptkbp:OMIM 601728
gptkbp:orthologInMouse Pten
gptkbp:pathway gptkb:PI3K-Akt_signaling_pathway
apoptosis
cellular senescence
gptkbp:PDB gptkb:1D5R
gptkbp:phosphorylates physical activity
gptkbp:regulates gptkb:PI3K/AKT_signaling_pathway
apoptosis
cell survival
cell growth
cell migration
cell cycle
cellular metabolism
gptkbp:subcellularLocation gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
gptkbp:symbol gptkb:PTEN
gptkbp:UniProtID gptkb:P60484
gptkbp:bfsParent gptkb:PI3K/AKT_signaling_pathway
gptkbp:bfsLayer 6