phosphatase and tensin homolog (PTEN)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene
gptkbp:alias	gptkb:MMAC1 gptkb:TEP1
gptkbp:dephosphorylates	gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:discoveredBy	gptkb:Peter_C._Steck
gptkbp:discoveredIn	1997
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000171862 5728
gptkbp:expressedIn	many tissues
gptkbp:function	gptkb:tumor_suppressor phosphatase activity lipid phosphatase
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	9588
gptkbp:inhibitedBy	cell proliferation cell survival angiogenesis cell migration cell adhesion
gptkbp:length	403 amino acids
gptkbp:locatedOnChromosome	gptkb:chromosome_10
gptkbp:molecularWeight	47 kDa
gptkbp:mutationAssociatedWith	gptkb:Bannayan–Riley–Ruvalcaba_syndrome gptkb:cancer gptkb:Cowden_syndrome gptkb:endometrial_cancer gptkb:glioblastoma prostate cancer
gptkbp:OMIM	601728
gptkbp:orthologInMouse	Pten
gptkbp:pathway	gptkb:PI3K-Akt_signaling_pathway apoptosis cellular senescence
gptkbp:PDB	gptkb:1D5R
gptkbp:phosphorylates	gptkb:physical_activity
gptkbp:regulates	gptkb:PI3K/AKT_signaling_pathway apoptosis cell survival cell growth cell migration cell cycle cellular metabolism
gptkbp:subcellularLocation	gptkb:cell_membrane gptkb:nucleus gptkb:cytoplasm
gptkbp:symbol	gptkb:PTEN
gptkbp:UniProtID	gptkb:P60484
gptkbp:bfsParent	gptkb:PI3K/AKT_signaling_pathway gptkb:protein_tyrosine_phosphatase_family
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	phosphatase and tensin homolog (PTEN)