|
gptkbp:instanceOf
|
nuclear receptor
|
|
gptkbp:activatedBy
|
gptkb:GW3965
T0901317
|
|
gptkbp:alias
|
gptkb:NR1H3
gptkb:Liver_X_receptor_alpha
gptkb:OX_receptor_alpha
gptkb:RLD-1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:diabetes_mellitus
gptkb:metabolic_syndrome
atherosclerosis
|
|
gptkbp:coactivator
|
gptkb:SRC-1
|
|
gptkbp:corepressor
|
gptkb:NCoR
|
|
gptkbp:dimerizationPartner
|
gptkb:retinoid_X_receptor_(RXR)
|
|
gptkbp:discoveredBy
|
1995
|
|
gptkbp:DNABindingDomain
|
zinc finger
|
|
gptkbp:encodedBy
|
gptkb:NR1H3_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000126368
|
|
gptkbp:fullName
|
gptkb:Liver_X_receptor_alpha
|
|
gptkbp:function
|
regulation of cholesterol, fatty acid, and glucose homeostasis
|
|
gptkbp:gene
|
gptkb:NR1H3
|
|
gptkbp:HGNC_ID
|
7961
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LXRα
|
|
gptkbp:inhibitedBy
|
gptkb:GSK2033
|
|
gptkbp:ligand
|
oxysterols
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p11.2
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:MIMNumber
|
602423
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:proteinFamily
|
gptkb:nuclear_hormone_receptor_family
|
|
gptkbp:regulates
|
gptkb:ABCA1_gene
gptkb:CYP7A1_gene
gptkb:SREBP-1c_gene
true
|
|
gptkbp:speciesHomolog
|
gptkb:mouse_LXRα
gptkb:rat_LXRα
|
|
gptkbp:subfamily
|
gptkb:nuclear_receptor_subfamily_1_group_H_member_3
|
|
gptkbp:tissue_specificity
|
liver
adipose tissue
macrophages
intestine
|
|
gptkbp:UniProtID
|
P55055
|
|
gptkbp:bfsParent
|
gptkb:LXR
|
|
gptkbp:bfsLayer
|
6
|