LXRα

URI: https://gptkb.org/entity/LXRα

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:nuclear_receptor
gptkbp:activatedBy	gptkb:GW3965 T0901317
gptkbp:alias	gptkb:NR1H3 gptkb:Liver_X_receptor_alpha gptkb:OX_receptor_alpha gptkb:RLD-1
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:diabetes_mellitus gptkb:metabolic_syndrome atherosclerosis
gptkbp:coactivator	gptkb:SRC-1
gptkbp:corepressor	gptkb:NCoR
gptkbp:dimerizationPartner	gptkb:retinoid_X_receptor_(RXR)
gptkbp:discoveredBy	1995
gptkbp:DNABindingDomain	zinc finger
gptkbp:encodedBy	gptkb:NR1H3_gene
gptkbp:Entrez_Gene_ID	ENSG00000126368
gptkbp:fullName	gptkb:Liver_X_receptor_alpha
gptkbp:function	regulation of cholesterol, fatty acid, and glucose homeostasis
gptkbp:gene	gptkb:NR1H3
gptkbp:HGNC_ID	7961
gptkbp:inhibitedBy	gptkb:GSK2033
gptkbp:ligand	oxysterols
gptkbp:locatedOnChromosome	gptkb:chromosome_11p11.2
gptkbp:location	gptkb:nucleus
gptkbp:MIMNumber	602423
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:phosphorylates	regulates activity
gptkbp:proteinFamily	gptkb:nuclear_hormone_receptor_family
gptkbp:regulates	gptkb:ABCA1_gene gptkb:CYP7A1_gene gptkb:SREBP-1c_gene true
gptkbp:speciesHomolog	gptkb:mouse_LXRα gptkb:rat_LXRα
gptkbp:subfamily	gptkb:nuclear_receptor_subfamily_1_group_H_member_3
gptkbp:tissue_specificity	gptkb:adipose_tissue liver macrophages intestine
gptkbp:UniProtID	P55055
gptkbp:bfsParent	gptkb:LXR
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	LXRα