Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
collagen |
| gptkbp:alternativeName |
gptkb:collagen_type_I
fibrillar collagen collagen I |
| gptkbp:aminoAcidContent |
rich in glycine
rich in hydroxyproline rich in proline |
| gptkbp:associatedWith |
Ehlers-Danlos syndrome
osteogenesis imperfecta dermatosparaxis |
| gptkbp:biosynthesized_from |
fibroblasts
osteoblasts |
| gptkbp:composedOf |
one alpha-2 chain
two alpha-1 chains |
| gptkbp:crosslinking |
forms fibrils
stabilized by covalent bonds |
| gptkbp:degradedBy |
collagenase
|
| gptkbp:discoveredBy |
Gustav von Bunge
|
| gptkbp:discoveredIn |
late 19th century
|
| gptkbp:encodedBy |
gptkb:COL1A1_gene
gptkb:COL1A2_gene |
| gptkbp:foundIn |
gptkb:bone
gptkb:skin cornea blood vessels organs tendon ligament |
| gptkbp:function |
structural support
provides tensile strength |
| https://www.w3.org/2000/01/rdf-schema#label |
type I collagen
|
| gptkbp:majorComponentOf |
extracellular matrix
|
| gptkbp:molecularWeight |
~300 kDa
|
| gptkbp:percentageOfTotalCollagen |
~90% in bone
|
| gptkbp:postTranslationalModification |
glycosylation
hydroxylation of lysine hydroxylation of proline |
| gptkbp:solubility |
insoluble in water
|
| gptkbp:structure |
triple helix
|
| gptkbp:usedIn |
tissue engineering
medical devices wound healing cosmetic products |
| gptkbp:bfsParent |
gptkb:CTX_(C-terminal_telopeptide)
|
| gptkbp:bfsLayer |
7
|